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Cell 184(17) de Brito Cristina, Toscano E, Leandro Marciano Vieira , Boni Rocha Dias B et al (2021) NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL- in sclerotic hippocampi [J]
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The study was published in JAMA Ophthalmology and had more than 16,000 participants
The placebo-subtracted effect of semaglutide was 12.40 [7.13, 17.67], 15.60 [12.65, 18.55], 17.00 [13.64, 20.36], and 13.90 [10.78, 17.02]% for overweight, class I, II, and III of obesity, respectively (all p 39.9 kg/m2, only one study with semaglutide reported data on incident MACE, showing no between-group differences
Patients on Rybelsus combined with sulphonylureas or insulin should be advised to carry glucose tablets or a fast-acting carbohydrate source at all times and ensure family members or colleagues know how to recognise and respond to hypoglycaemia
Higher protein intake may help mitigate this risk
