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Hydrolysis of Amides It is possible to hydrolyze amides with strong acids or bases in harsh reaction conditions: The mechanism for both hydrolysis reactions involves the two steps of addition-elimination reactions

FIGURE 4 The CBL primarily catalyzes the cleavage of cystathionine, producing homocysteine, pyruvate, and ammonia

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Intranasal delivery extends the effective CNS half life because the peptide is transported directly along olfactory and trigeminal nerve pathways into cerebrospinal fluid and hippocampal interstitial space, bypassing systemic circulation and hepatic metabolism

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