When NNMT is overactive as it tends to be in fat tissue, and increasingly with age and obesity it siphons off the very raw material your cells need to keep NAD+ topped up
Take 2 capsules, twice daily, or as directed by your healthcare professional
Takano, 2015)
A number of research confirmed a strong involvement of oxidative stress in the pathophysiology of neurodegenerative diseases through a variety of mechanisms including induction of oxidation of macromolecules such as nucleic acids, proteins, lipids, mitochondrial dysfunction, glial cell activation, amyloid deposition, apoptosis, and proteasome dysfunction [3, 5, 10, 11]
Transfection of Cyp2E1 [145] or induction of Cyp2E1 by dimethyl sulfoxide (DMSO) [139], can restore at least in part the metabolic capacity of HepG2 cells but the overall gene expression profile of HepG2 cells shows low similarity to primary human hepatocytes [146, 147]
Pullar et al., 1972