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Description

It was approved by the US Food and Drug Administration (FDA) as a 2-line drug for T2DM patients in 2005, and was marketed in China in 2009

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Notably, the treatment demonstrated antiallodynic effects, meaning that it alleviated pain caused by stimuli that wouldnt normally induce pain in a non-inflamed subject

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Western blotting with anti-FLAG and anti-p53 antibodies revealed that 5-FU treatment induced the polymer formation of GST WT -p53 but had no effect on GST 4QN -p53 in H1299 and HT-1080 cells (Fig

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