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The molecular mechanism underlying lactate-induced downregulation of ACSL4 via MCT1 remains incompletely elucidated, although accumulating evidence suggests a potential involvement of the lactate-induced STAT3 signaling pathway (197,198)

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These results agreed with previous short- and medium-term studies, which also found that L-carnitine was able to reduce other markers of muscle damage, such as cytosolic serum proteins [5,11]