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Scheper, H., Wubbolts, J
Precision medicine approaches should enroll participants based on biological signatures rather than broad diagnostic categories, including glutathione status, lactate to pyruvate ratios, N acetyl aspartate, NRF2 related profiles, electron transport chain complex activity, and the presence of folate receptor alpha autoantibodies in cerebral folate deficiency
GPX4 is strictly constrained by upstream reductive systems, lipid substrate sources, and alternative antioxidant networks
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