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Zaka M, Rafi MA, Rao HZ, Luzi P, Wenger DA

Garcia-Echeverria et al (2004) presented a new compound (a pyrrolo[2,3-d] pyrimidine) that although inhibiting the IGF-1R and IR TK equipotently in cell-free systems, exhibited several-fold selectivity for the IGF-1R in a cellular context and reduced the growth of IGF-1R positive fibrosarcomas in vivo

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15 In healthy, elderly populations, high circulating levels of TNF and IL-6 predict mortality, regardless of comorbidities, whereas in cohorts of frail, older individuals, these cytokines may represent risk factors for atherosclerosis, T2D, AD, thromboembolic complications, and are associated with sarcopenia and muscle loss

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