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4 Senotherapy Senotherapy is an experimental treatment method aimed at eliminating the threat arising from the accumulation of senescent cells [97]

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-20.2% vs -13.7% at 72 weeks

When mitochondrial depolarization and proteasome-dependent rupture of the outer membrane occur, PHB2 binds the autophagosome membrane-associated protein LC3 via the LC3 interaction region structural domain (Fig