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Introduction How is Melatonin Produced

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Leveraging the University of California Health Data Warehouse enabled a realworld analysis of 6,871 patients with primary colon cancer and rigorous adjustment strategies to probe whether GLP1 RA exposure relates to fiveyear mortality. At the end of the study, researchers found that participants with colon cancer taking GLP-1 medications had a 15.5% mortality risk within 5 years, compared to 37.1% in participants not taking the drugs

These data indicate the implication of PSPH in the regulation of the aggressive and immunosuppressive tumor microenvironment in GBM, which could be targeted by sertraline/chloroquine combination treatment

Disclosure of interest: Frank te Nijenhuis: nothing to disclose