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These factors activate hepatic stellate cells and fibroblasts to produce extracellular matrix proteins involved in collagen synthesis, with Col1a1 as one major player (2729)

however, some are more damaging than others

Further examining the change in gene expression revealed that an extensive number of these metabolic genes are increased in expression both at 24 h and 48 h (Extended Data Fig

Pll, D., Katona, E., Juhsz, M

In a diet-induced rat model of MASH, genistein supplementation reduced multiple markers of severity of liver inflammation including hepatic TNF- level, inflammatory cell inflammation, and overall histological severity (161)

et al., 2015)