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BioMed Res Int

This compounds across multiple exposures, which is why strict cold chain discipline matters from the moment of reconstitution

[1] Evidence accumulated over four decades indicates that topical tretinoin accelerates epidermal turnover, refines follicular architecture, and stimulates dermal collagen remodeling, while azelaic acid provides comedolytic, antimicrobial, and tyrosinase-inhibiting activity

Similar concerns apply to other supplements, including melatonin, where long-term safety remains an area of active investigation