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Until the body becomes efficient at using fat for fuel, this temporary reduction in readily available energy may be perceived as fatigue

The skin's natural pigment called melanin helps to keep skin color light and fresh

The study looked at the change from baseline in LFC as assessed by MRI-proton density fat fraction (MRI-PDFF) at week 52

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Functional characterization of thioredoxin 3 (TRX-3), a Caenorhabditis elegans intestine-specific thioredoxin

Direct answer: Extreme thirst, dry mouth, very dark urine, reduced urination, fatigue, sunken eyes, light-headedness, or fainting may signal dehydration