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Nausea: Uncommonly reported, usually with higher doses

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These signals include peptides secreted by the gastrointestinal tract (CCK, GLP-1), the pancreas (glucagon and insulin) and adipose tissue (leptin)

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When GLP-1 Therapy Makes Sense for Hyperthyroid Weight Loss Semaglutide becomes a practical option when hyperthyroidism is controlled (TSH and free T4 in target range) and your endocrinologist approves its use