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Description

Brain and Nervous System Function: Crosses the blood-brain barrier to support the production of acetylcholine, a neurotransmitter involved in memory and learning

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Direct effects on cellular proliferation A genetically engineered murine model of pancreatic intraepithelial neoplasia (PanIN) to PDAC progression ( LSL-Kras G12D ;Pdx1-Cre, KC ) treated with exenatide demonstrated architectural changes of loss of polarity and micropapillary formation following 12 weeks of therapy 18

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Currently: Victoza is approved for children with Type 2 diabetes as young as ten years old Both Saxenda and Wegovy are approved for children 12 years and older The FDA is currently considering approving liraglutide for children as young as six years old The Canadian Medical Association Journal (CMAJ) has also advised using GLP-1 drugs and surgery, when appropriate, representing a growing international consensus on these treatments

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[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Thethi TK, Pratley R, Meier JJ

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