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A recent systematic review and meta-analysis of 21 randomized controlled trials mostly in patients with existing CVD found that folic acid supplementation slightly lowers systolic (1.10 mm Hg) and diastolic (-0.24 mm Hg) blood pressure (105)

Accordingly, the expression changes of L2HGDH by sg L2HGDH , L2HG treatment, or L2HGDH OPT led to decreased or increased DNA hydroxymethylation in the CBS promoter CpG island (Fig

Neuroscience Research , 55 (3), 255263

The analysis revealed a large effect size for saffron supplementation compared to placebo in reducing depressive symptoms (mean effect size = 1.62, p 60 years) with MDD found that saffron 30 mg/day had similar antidepressant effects to sertraline 50 mg/day after 6 weeks

Plant Cell 19:30373057