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Introduction Currently, the calcineurin inhibitor (CNI) Tacrolimus (Tac) is the most prescribed immunosuppressant after renal transplantation (RTx), as approximately 95% of recipients are discharged with a Tac-based immunosuppressive regimen ( The Kidney Disease: Improving Global Outcomes (KDIGO) guideline as the main cornerstone immunosuppressant after RTx ( Besides the adverse effects, the high inter- and intraindividual variability (IPV) in pharmacokinetics (PK) and -dynamics pose a major challenge to physicians at reaching a given target trough level within the narrow therapeutic window

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