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In a clinical trial in 13 subjects with type 2 diabetes, participants consumed a high-AGE meal before and after a 3-day course of benfotiamine, 1050 mg per day

This cellular die-off leads to excessive increases in uric acid

Santinami, R

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The findings indicated that patients on GLP-1RAs and/or DPP-4 inhibitors experienced better disease outcomes compared to those on different treatments, accompanied by an incidence rate ratio (IRR) of 0.52 (95% confidence interval: 0.420.65) [227]