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In mammals, paracetamol is detoxified in the liver where, at low doses, sulfation and glucoronidation result in the formation of the inactive, non-toxic sulfate and glucuronid conjugates (Scheme 1)
Oddziaywanie reaktywnych form tlenu i azotu z biakami
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YangXHeiCLiuPSongYThomasTTshimangaSet alInhibition of mTOR pathway by rapamycin reduces brain damage in rats subjected to transient forebrain ischemia
Similar to the mechanism GSTs use for catalyzation of redox reactions, the mechanism for detoxification first involves the binding of two substrates to the enzyme
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