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Here, we provide a conceptual overview of the recurring mechanistic themes by which metabolites shape the biology of immune cells, epithelium and neurons of the gastrointestinal tract

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Nevertheless, since GSH cannot be administered directlybecause of its insufficient absorption, stability and solubilityanalogues have been obtained, through modifications at the -glutamyl, cysteine and glycine moieties, and/or the functionalisation of the central cysteine, that are able to inhibit the activity of GSTs 69,87,105

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21 The biology of glutathione in aging-related nuclear cataracts will be further considered below