Certain probiotic strains may help support: Gut barrier function Production of beneficial metabolites GLP-1 secretion pathways Although research remains emerging, probiotics represent one of the most exciting future areas in metabolic health
For weight loss, other options include Saxenda (liraglitude) and Zepbound (tirzepatide)
Incidence of fractures in patients with type 2 diabetes in the SAVOR-TIMI 53 trial
10.3322/caac.21654 111 SimonE.ClinoiuL
Clinical trials and real-world data consistently show significant weight loss from treatment with Ozempic, Semaglutide and Tirzepatide: Unfortunately, weight regain is a well-documented phenomenon after discontinuation of treatment: SURMOUNT 4 trial- Weight regain after stopping Tirzepatide after 36 weeks versus continuation of treatment Beyond weight regain, the discontinuation of GLP-1 agonists may reverse cardiometabolic benefits: Ongoing trials (e.g., SELECT and SURPASS-CVOT) aim to clarify whether continued use is necessary for sustained cardiovascular risk reduction
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