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Some clinical trials have shown modest, temporary reductions in melanin index with consistent oral use, but reviews of this research describe the effect as inconsistent between studies and dependent on continued use, not a one-time or lasting change

doi: 10.1038/sj.ijir.3901043 173 CoronaGMannucciEJanniniEALottiFRiccaVMonamiMet al

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What this mechanism does NOT prove: Demonstrating a receptor interaction or pathway upregulation in rat tissue or cell culture does not confirm a clinically meaningful effect in humans at any given dose

Its particularly concerning that modern commercial farming practices have created a reduced trace mineral content in the soil

Immunity 40:248261