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The -glutamyl amino acid can be transported back into the cell where -glutamyl cyclo-transferase (GCT) releases the acceptor amino acid to form 5-oxo-proline, the latter of which is converted back to glutamate by oxo-prolinase and used for GSH synthesis

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Notably, these benefits were achieved without undesirable estrogenic effects on the uterus

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As a result, a higher proportion of E3 remains unbound in circulation and is thus able to exert its biological activity