The risk of bias assessment indicated that all studies had a good quality
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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Mounjaro) and chronic weight management (Zepbound)
It works by activating GLP-1 receptors, which help control blood sugar and reduce hunger
The drug received approval from both the US FDA and the European Union in 2022 for the treatment of type 2 diabetes, demonstrating signicant glucose-lowering and weight-loss efects in multiple clinical trials
These are signals, not conclusions but theyre coming directly from patients, unprompted, and thats worth paying attention to, says the first author, Neil Sehgal, a doctoral student at the University of Pennsylvania in Philadelphia