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This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

Keith Lafferty MD, Fort Myers on October 10, 2025

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While management of the underlying cause of the peripheral neuropathy (if applicable) is essential, treatment of the peripheral neuropathy itself includes combination of oral medication, prescription creams, physical therapy, and regenerative medicine

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