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10.1007/s13770-024-00668-8 98 WangK.DengY.XuC.YanR.WangH.ZhangY.et al (2025)

Curr Rheumatol Rep 20(11):72

It has been suggested that the inflammasome and IL-1 are involved in melanocyte loss, as staining for these markers was highly positive in the perilesional skin of patients with active vitiligo [59]

The triple-agonist hypothesis predicts that GLP-1R and GIPR co-agonism will offset the glycemic effects of glucagon receptor activation while preserving its energy-expenditure benefits, a balance that retatrutide's structural design appears to achieve