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Role of Intracellular pH in Insulin Secretion Glucose uptake and metabolism by -cells not only activates insulin secretion but also induces maturation of of immature secretory vesicles promoting further processing of proinsulin

10.1146/annurev.immunol.25.022106.141618 Annu

This study strengthens previous research conducted by the team because it needs to check the reliability of the previous study, except that the previous study used two doses and examined each hormone separately

The accumulation of lipid peroxides has been shown to exacerbate oxidative stress, thereby amplifying the activation of PARP1 and contributing to mitochondrial dysfunction, further promoting the release of AIF and triggering the parthanatotic cell death process [141]

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