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A multiple testing procedure for clinical trials

Opening at 2 mg weekly rather than 4 mg markedly softens early GI effects, and any higher weekly dose simply calls for more than one vial or a split across two sites

Some research suggests berberine may improve insulin sensitivity and glucose metabolism, with animal studies indicating potential effects on GLP-1 secretion

Trulicity is also approved in adults with type 2 diabetes to reduce the risk of major heart problemslike heart attack, stroke, or deathespecially for those who already have heart disease or have many risk factors for it

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NCT04537637