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This applies to patients who fail to achieve individualised glycemic targets despite receiving metformin and an SGLT2 inhibitor (SGLT2i) or who have a contraindication to these medications [16]

During weight loss, oxidative stress increases as adipose tissue releases stored toxins and cellular turnover accelerates

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Concurrent treatment of the GnRH agonist goserelin with chemotherapy provides some benefits to fertility preservation in breast cancer patients (Moore et al, 2015), however, these effects are moderate and the interpretation of these data is complicated by differences in the proportion of women seeking pregnancy (Oktay et al, 2015)

Until that happens, proceed with actual caution is the only honest advice anyone can give you