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Alcohol acts on neurotransmitter receptors, including GABA, glutamate, and dopamine, with each receptor contributing to various physiologic effects, with chronic alcohol administration increasing tolerance and addiction ( The brains of individuals with alcohol dependence have increased proinflammatory cytokines, chemokines, microglial markers, and inflammasome proteins (Rubio-Araiz et al., 2017)

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Curr Opin Clin Nutr Metab Care 18:552558 Dinan TG, Cryan JF (2017a) Brain-gut-microbiota axis and mental health

Moderate traumatic brain injury, acute phase course and deviations in physiological variables: an observational study

[12] [13] Check with your doctor before beginning an exercise routine if you are at all concerned about your current level of health and/or physical fitness