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This systems activity declines with aging, and restoring it helps cells maintain internal cleanliness, likely contributing to GHK-Cus observed anti-aging effects at the cellular level

GSH, the most abundant antioxidant in the heart, plays a fundamental role in normalizing a redox homeostatic mechanism that was shifted toward oxidative or reductive stress

Transcriptional regulation by Nrf2

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Abstract Glutathione (GSH), the most abundant intracellular low molecular weight thiol, has diverse physiological roles, and altered GSH status has been implicated in a number of chronic, acute, and age-related diseases, as well as the aging process itself