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Journal of Autism and Developmental Disorders, 37(4), 628-636

Starting in the 1920s, people began taking 2,4-Dinitrophenol (DNP) which caused dramatic weight loss by making mitochondria less efficient (see our Mitochondria May blog post for more information)

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

suddenly, the focus on that goal was gone