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Propionyl-L-carnitine (200 mg/kg/day, p.o., 4 weeks) corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity [6]

Dosage adjustments are made as necessary to achieve optimal therapeutic outcomes

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By integrating these dietary, exercise, and lifestyle strategies, individuals can create a holistic approach to achieving and maintaining a healthier weight and overall well-being

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If retatrutide shows cardiovascular benefit similar to or better than semaglutide, it would significantly strengthen the case for approval and potentially expand the labeled indications