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Assessment of growth parameters and life span of GHR/BP gene-disrupted mice

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Deletion of phosphatase Pten protein is often detected in specimens of human prostate cancer, and the effect of selenium was examined by using mice lacking this gene, it was found that a large number of senescent cells could be detected in the defective parts of the prostate gland after 4 weeks of continuous treatment with methyl selenate, indicating that selenium-induced cellular senescence can indeed inhibit tumorigenesis (164)

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