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In cultured astrocytes, the truncated isoform of the TrkB receptor (TrkB-T1, also known as TrkB-Tc) mediates rapid intracellular Ca 2+ transients in response to brief BDNF exposure

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The results from this study may reveal an important basis underlying the gender-associated differences in the longevity and the susceptibility to certain age-related diseases, and also further suggest that the decreased synthesis, which is mainly due to the down regulation of GCL gene expression, may be responsible for the age-associated decline in GSH content

Glutathione metabolism of the brainthe role of astrocytes

Sesma JI, Weitzer CD, Livraghi-Butrico A, Dang H, Donaldson S, Alexis NE, et al

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