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53 Interestingly, studies suggest male infertility (except in cases that can be attributed to obstruction) may be an early sign of cancer, other impending disease, and death

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Simultaneously, the proportion of pro-inflammatory species ( Ruminococcus gnavus , Fusobacterium nucleatum , Prevotella copri ) increases, enhancing pro-inflammatory cytokine secretion and reducing SCFA production along with tryptophan-derived immunomodulatory metabolites, thereby promoting insulin resistance ( Functional features of the microbiota also play a key role

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