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PE-22-28: TREK-1 Channel Blockade# PE-22-28 (Gly-Val-Ser-Trp-Gly-Leu-Arg) is a synthetic 7-amino acid peptide derived from spadin, itself an endogenous peptide released by proteolytic processing of sortilin (neurotensin receptor-3)

Semaglutide showed a reporting odds ratio of 2.46 (95% CI: 2.14-2.83) for alopecia

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There was karyopyknosis and degeneration of the Purkinje cells of the cerebellar cortex, and a progression from mild to marked karyopyknosis of the cortical neurons and pyramidal cells of the hippocampus