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CT-388 and CT-868, developed by Carmot Therapeutics, are GIPR/GLP-1R agonists under investigation in obese patients, including those with type 1 diabetes (NCT04838405, NCT06062069)

Instead, Cys497 hTrxR1 is sandwiched between Ser415 hTrxR1 and Ser111 hTrxR1 , the latter being within hydrogen bond distance (3.6 ) to a strictly conserved His108 hTrxR1 (Fig

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