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In addition to reducing H 2 O 2 and small molecule hydroperoxides, GPX4 is also capable of reducing complex lipid compounds
doi: 10.1016/j.bbi.2016.12.010 62 SeveranceEGAlaediniAYangSHallingMGressittKLStallingsCRet al
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Ferroptosis with characteristic accumulation of oxidized phospholipids (or their breakdown products) in myocardial and renal tissue is responsible for ischemia-reperfusion injury, which is a detrimental factor for cardiac damage and MODS in COVID-19 patients 499
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