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ABCB1), MRP1 (ABCC1), and BCRP (ABCG2) utilize ATP hydrolysis to actively extrude chemotherapeutic agents from the cytosol, markedly reducing intracellular drug accumulation and promoting resistance (34)

6.2 Oral delivery strategies for flavonoids Despite their diverse pharmacological activities, the systemic application of flavonoids remains constrained by limited aqueous solubility, low oral bioavailability, rapid metabolic clearance, and insufficient targeting to skin and immune tissues

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