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By selectively blocking NNMT, 5-Amino-1MQ is investigated for its ability to preserve cellular NAD+ pools, reduce methylation of nicotinamide to inactive 1-methylnicotinamide (1-MNA), and enhance sirtuin activity and energy metabolism
Studies in animals show that systemic administration produces healing effects at distant sites
Ann Intern Med 92:511511 ODell JR, Zetterman RK, Burnett DA (1986) Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic
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