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Contraindications include personal or family history of medullary thyroid carcinoma, history of multiple endocrine neoplasia type 2, severe gastrointestinal disease, and certain pregnancy considerations

Parker VER, Robertson D, Wang T, Hornigold DC, Petrone M, Cooper AT, et al

Understanding your options and what to expect Delivery timing and how the process works General questions before you decide UK Guidance on GLP-1 Use Before Surgery Several UK professional bodies have issued guidance regarding GLP-1 receptor agonists in the perioperative period, reflecting growing clinical experience and emerging evidence

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Lipophilic side-chain substitutions and conjugation with transport-facilitating groups (e.g., fatty acids, bile acid conjugates) can further increase membrane affinity and intestinal residence time