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4244 Recently, a single cell gene expression-based informatics approach identified pacemaker cells as cellular targets for GLP-1 RAs, 44 suggesting that at least part of the positive chronotropic effect may be mediated through the sinus node

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Unlike traditional protocols that may introduce higher doses rapidly, microdosing is intended to Maintain Receptor Sensitivity: By keeping dosing at the lowest effective level, the goal is to keep receptors sensitive and responsive rather than fatigued

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In fact, the summation of the data presented here suggests that this would be the case in patients with T2D, but it also points to a potential benefit for patients with cancer who may not have a current diagnosis of T2D