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This method is particularly useful for peptides that target cognitive or neurological functions, as the nasal cavity provides a pathway that is close to the central nervous system

Facilitation of hippocampal synaptogenesis and spatial memory by C-terminal truncated Nle 1 -angiotensin IV analogs

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Additionally, its effects on gut motility and bowel function mean it warrants caution in patients with bowel obstruction or severe gastrointestinal surgery history