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The fear that hyperkalemia will cause cardiac arrhythmias often prompts clinicians to stop or reduce kidney-protective therapy, including ACEis, or ARBs or MRAs, and if these drugs are not restarted, then people miss out on their kidney- and heart-protective benefits

Similarly, those who have a personal history of pancreatitis should also avoid taking these medications

Instead, research suggests these medications may actually provide some cancer-protective benefits, particularly through weight loss and other metabolic improvements

Similar effects have been reported for liraglutide, which targets overlapping molecular pathways involved in smooth muscle tone regulation

The announcement adds to a string of setbacks in the company's bid to win a slice of the booming market for GLP-1s, which mimic certain gut hormones to tamp down appetite and regulate blood sugar

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial