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Even when coverage exists, high deductibles and copays can make treatment inaccessible

Time window and exit rules: a sufficient treatment window (36 months) should be reserved to achieve clinically meaningful weight loss (typically threshold of 5%10%) alongside IR improvement

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95% CI, 0.78-0.95) and without type 2 diabetes (HR = 0.82

The approach is intended to build on the mechanisms of existing incretin-based obesity medicines, including Lilly's dual GIP/GLP-1 agonist tirzepatide

This is highly valuable for treating male hypogonadism, preserving fertility, and maintaining normal sperm production when a patient is undergoing hormone replacement therapy