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In about 70% of people, the first symptoms appear in the limbs usually starting with hand weakness (60%) or leg weakness (40%)

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They may recommend dose adjustments, additional investigations (such as C-peptide levels to assess beta-cell function), combination therapy with other diabetes medications, or switching to an alternative GLP-1 formulation or drug class

The PI3K/AKT/mTOR signaling pathway has been implicated in the apoptotic effects of certain plant extracts on cancer cells [58]

Alcohol and hepatocellular carcinoma

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