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Research has shown that the omega 3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) can reduce the inflammatory cytokines COX-2, TNF-alpha and IL-1 beta (Kang JX, Weylandt KH, 2008,Adam O, 2003)

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Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

In addition, dapagliflozin attenuated the progression of diabetic cardiomyopathy by activating AMPK, mTOR and NOD-like receptor 3 (NLRP3) inflammasome in T2DM mice [105]

Professional liability considerations are important, as the use of non-FDA approved compounds may carry different legal risks compared to approved medications

Moreover, SCFAs, dose-dependently, which effects dependent on the specific SCFA, segment of the colon animal species and experimental models, may impact IBS-D with increased transit rate