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Liquid chromatographymass spectrometry analysis of metabolites All liquid chromatographymass spectrometry (LCMS) sample analyses and metabolite quantification were performed with sample identities blinded to the analyst

All calculations are estimates and may vary based on product concentration, compounding standards, and individual prescriptions

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PMC2930015 7

Nevertheless, DKP is a known metabolite of AX that can arise as well by thiol-independent mechanisms, including the acidic degradation of AX (Nagele and Moritz, 2005)

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