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Ellul-Micallef R

Multiple colon tumour areas were assessed per animal, and the average percentage of CC3 + cells per tumour is shown

Garcia AN, Casanova NG, Valera DG, Sun X, Song JH, Kempf CL

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HIF-1 activates glycolysis-related genes, including pyruvate dehydrogenase kinase 1 (PDK1), increasing the conversion of glucose to pyruvate and subsequently to lactate by inactivating PDH, which is considered critical for metabolic adaptation to hypoxia [74] [Figure 1F]

prolonged overactivation may promote oncogenic pathways or, as seen in clinical trials with bardoxolone methyl, adverse renal outcomes (Pergola et al., 2021)