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Current research suggests the interaction risk exists primarily when gastrointestinal side effects are significant, making individual assessment critical

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GLP-1 (glucagon-like peptide-1) medications, often prescribed for managing diabetes or aiding weight loss, can sometimes impact nutrient absorption, leaving users with vitamin deficiencies they might not even realize they have

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Use of SGLT2 inhibitors was low in STEP-HFpEF, as patients with diabetes were excluded, and these agents were not yet approved for treatment of HFpEF during the trial conduct

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